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7.2 Drugs that can both enhance radiosensitivity and reduce radiation-induced injury Although optimal radiotherapy effects cannot be achieved solely through the ferroptosis pathway, certain drugs can not only inhibit ferroptosis to mitigate radiation damage but also enhance radiosensitivity through their selective cytotoxic effects on tumor cells

Elevated superoxide generated from dysfunctional mitochondria promotes the formation of excess H 2 O 2 , the substrate for myeloperoxidase (MPO)-mediated hypochlorous acid (HOCl) synthesis and the generation of the inammatory biomarker, 3-chlorotyrosine (3-CT)

BMC Complement

Blakemore, W

The sex ratio was 11:4 (male:female)